Background and Aim: ACUTE MYOCARDIAL infarction (AMI) is one of the most common diseases today. One of the important issues which are under attention of searchers is to diagnose AMI accurately using paraclinic methods. The aim of this study was to determine the level of two important biochemical markers of AMI cardiac TROPONIN I and T. Materials and Methods: This study was a descriptive-analytic study, which was performed on 100 patients in whom-according to criteria of WHO and references-diagnosing of AMI is definite, in second day of admission in CCU, cardiac markers including TROPONIN I using qualitative immunochromatography assay and cardiac TROPONIN T using third generation cTnT detection assay (CARDIAC) and also total CREATINE KINASE (CK) was measured and record for patients. This information was recorded in a special data sheet and than analyzed by using SPSS, Chi-Square and Hest. Results: Mean age of patients was 59.73 ± 12.57.38 patients were women and 62 of them were men. 83 of patients ( 83%) had positive TROPONIN I, 97 (97%) had values of TROPONIN T more than 0.1 mg/ml (indicating AMI) and also 93 patients (93%) had total CK value more than normal. Conclusion: TROPONIN T is a more sensitive marker for diagnosis of AMI comparing with other cardiac markers of AMI in 24 h after AMI.

Background: MYOCARDIAL Infarction is the most frequent diagnosis in the admitted patients in Western Countries that is important to diagnose rapidly. This study was designe do determine the most sensitive double marker diagnostic method of CREATINE KINASE- Mb, myoglobin and TROPONIN I in ACUTE MYOCARDIAL infarction.Materials and methods: This descriptive diagnostic test study performs on patients with cardiac angina that began between 4-24 hr without MI history and don't receive cardiac electroshock. Quota sampling was done on 256 emergency patients in two 4-14 hour and 15-24 hour began pain group. Collected data analyzed with SPSS 11.5 software.Results: The most sensitive and specific double marker in the period was TROPONIN I-Myoglobin (97.3%, 98.1%) and in the second period was CREATINE KINASE- Mb-TROPONIN I (100%, 96.3%).Conclusions: The perfect method for the first period the combination up TROPONIN I-Myoglobin and for the second period is double markers CREATINE KINASE- Mb-TROPONIN I.

Background and Objective: Based on previous studies, the clinical sensitivity of cardiac TROPONIN I (cTnI) is higher than CREATINE KINASE MB (CK-MB) in diagnosing ACUTE coronary syndromes. The present study aimed to assess the diagnostic accuracy of cTnI and CK-MB biomarkers in diagnosing suspected MYOCARDIAL infarction (MI). Materials and Methods: In this descriptive study, 453 patients suspected of ACUTE coronary syndrome who visited the emergency department of Farshchian Hospital in Hamadan in 2017 with chest pain were included. Of these, 360 patients had MI, and 93 patients did not have MI. In order to measure serum levels of CK-MB and cTnI, blood samples were taken from patients at the beginning and one and six hours later. The sensitivity and specificity of CK-MB and cTnI enzymes in MI were compared. Results: The sample size of this research was 453 cases, of which 66.45% were male and 33.55% were female. The mean age of subjects was 65.28±14.38 years. The sensitivity and specificity of cTnI in the diagnosis of MI were 96.67% and 100%, respectively. The sensitivity and specificity of CK-MB in diagnosing MI were 81.11% and 12.90%, respectively. The positive and negative predictive values of cTnI were 88.57 and 100, respectively, while the positive and negative predictive values of CK-MB were 78.28 and 15%, respectively. The accuracy of cTnI in differentiating cases of MI from non-MI (97.35%) was higher than that of CKMB (67.08%). Conclusion: As evidenced by the obtained results, the sensitivity, specificity, and accuracy of cTnI detection in MI cases were higher than CK-MB. Therefore, TROPONIN is a better marker than CREATINE KINASE to identify patients with MYOCARDIAL infarction.

MYOCARDIAL infarction (MI) is one of the most important health burdens worldwide. Aspirin as an non- Steroid Anti-inflammatory drug, has been proven to be a protective factor to decrease the incidence, however its effect of MI size is still unknown. We designed this study to compare the biomarkers after MI in patients with and without aspirin intake. 378 patients were enrolled and the results showed lower cardiac TROPONIN T and CREATINE KINASEs in patients with protective dose of aspirin intake. In addition, CREATINE KINASEs were significantly higher in patients with no history of MI. We conclude that aspirin can reduce the size of the infraction. Also, higher enzymes can be due to higher muscle content in patient without MI history.

Introduction: Serum levels of cardiac TROPONIN (CTnI) and CREATINE KINASE (CK-MB) are two indicators of cardiac cell damage. The present study aimedto investigate the effect of different volumes of a high-intensity interval training (HIIT) course on serum CTnI and CK-MB levels in cardiac patients after MYOCARDIAL infarction (MI). Materials and Methods: In this semi-experimental study with pretest–, posttest design, thirty patients (50. 03±, 4. 32 years) with documented MI were selected voluntarily. Regarding the researchcriteria, all participants were randomly assigned into three groups (n=10 per group): Acontrol group and two high-volume HIIT training (HV-HIIT) and low-volume HIIT training (LV-HIIT)groups. The HV-HIIT group did exercisesthree days a week for 40 minutes, and the LV-HIIT group didexercises three days a week for 20 minutes. Blood samples were taken before and after the 12-week intervention. Statistical analysis of the variables was performedusingpaired t-tests, one-way analysis of variance, and Tukey's post hoc test. Results: At the end of the intervention, CTnI in the LV-HIIT and HV-HIIT groups decreased significantly (70% and 50%, respectively),however, no significant change was observed in the control group. CK-MB levels showed a significant decrease (26%)only in the LV-HIIT group. In the serum levels of CTnI, a significant difference was observed amongthe three groups (p=0. 035), and the results of Tukey's post hoc test showed a significant difference between the control and LV-HIIT groupsin terms ofdecreasedCTnI levels(p=0. 012). Conclusion: LV-HIIT training as an exercise strategy for cardiac rehabilitation programs after MI can improve cardiac injury indices more effectively than HV-HIIT and is associated with less cardiac damage and fatigue.

Introduction. MYOCARDIAL infarction is a common cause of mortality in patients with chronic kidney disease (CKD). Since TROPONINs I and T levels rise in CKD patients without any MYOCARDIAL cause, diagnostic value of cardiac TROPONINs is not high in these patients. This study aimed to evaluate the value of TROPONIN I and other cardiac biomarkers to differentiate ACUTE coronary syndrome in CKD patients. Materials and Methods. In this cross-sectional study, patients with stage 3 to 5 of CKD with typical chest pain were enrolled. TROPONINs I and T and other biomarkers were measured, and angiography was carried out in these patients. Cardiac biomarkers and other variables were evaluated in patients and compared with angiography results. Results. Ninety CKD patients with a mean age of 61. 67 ± 15. 87 years were enrolled. Angiography results were normal in 48. 9% of the patients, while it showed single-vessel disease in 14. 5%, twovessel disease in 23. 3%, and three-vessel disease in 13. 3%. Serum creatinine level, glomerular filtration rate, TROPONIN I level, and CREATINE KINASE level were not significantly different in patients with normal and abnormal angiography findings. The serum TROPONIN I, CREATINE KINASE, and CREATINE KINASE-MYOCARDIAL bound levels had no significant diagnostic values to differentiate abnormal angiography in CKD patients. Conclusions. Serum levels of cardiac TROPONIN I and CREATINE KINASE-MYOCARDIAL bound were not suitable to diagnose ACS in CKD patients (stages 3 to 5); therefore, we suggest using other diagnostic attempts in similar conditions. More evaluation is needed to confirm these findings.

Introduction: Current guidelines recommend using high-sensitivity TROPONIN (hs-cTnl) assays to manage patients with ACUTE coronary syndrome (ACS) symptoms. Despite this, bedside testing (POC) is commonly used in the emergency room, as it reduces the patient's response time and hospital stay. This study seeks to compare the results of the RAMP-cTnI test with the results of laboratory TROPONIN (hs-cTnl) as the gold standard. Methods: The present study was performed on 148 patients with suspected ACUTE coronary syndrome referred to Shiraz Namazi Hospital between March and July 2021. Blood samples were taken immediately from patients referred to the emergency department for POC and high-sensitivity TROPONIN test (as gold standard). Enzyme-Linked Fluorescent Assay (ELFA) was used to evaluate TROPONIN (cTnl). The POC test was performed using a RAMP device, which allows the rapid measurement of cTnl in the patient's bedside within 10 minutes using a whole blood sample. Results: Of the 148 patients, 35 were hs-cTnI positive. Sensitivity, specificity, the positive and negative predictive values of RAMP-cTnI compared to high sensitivity test with 95% confidence interval were 91. 42 (93. 63-85. 84), 94. 69% (97. 95%-87. 55), 84. 21% (93. 56-77. 82) and 97. 27% (99. 56-87. 82), respectively. Conclusion: The study showed that the quantitatively new RAMP-cTnI method was statistically acceptable with hs-cTnI regarding the accuracy of ACUTE MYOCARDIAL infarction. RAMP-cTnI was found to be suitable for detecting ACUTE MYOCARDIAL infarction in the emergency department.

Background: Percutaneous transluminal coronary angioplasty (PTCA) with or without stenting is a well established technique for coronary revascularization. The injury to the myocardium during the technique was investigated by measuring serum levels for cardiac TROPONIN I and activity of CREATINE KINASE MB Isoenzyme (CK-MB), the sensitive and relatively specific biomarkers of cardiac injury. In this study, to detect minor MYOCARDIAL injury after PTCA, we evaluated serum levels of CTNI and CK-MB after PTCA.Methods: The serum levels of CTNI and the activity of CK-MB were measured by standard methods in 100 patients undergoing elective PTCA, before and 12-24h after the procedure. Patients who had hepatic, renal and thyroid disease; recent MYOCARDIAL INFARCTION; electrocardiographic changes, chest pain and MYOCARDIAL infarction after intervention were excluded from our study.Results: Meaningful differences between the mean levels of CTNI in the samples obtained before and after PTCA; 0.67 ± 0.58 ng/ml VS 1.19 ±0.94 ng/ml (P= 0.000) and those of CK-MB activities; 22.89±8Iu/l VS 26.38±13.39 (P=0.010) were noticed. Stenting place had no effect on the measured parameters. Relationships between history of Hypertension, Diabetes, Hyperlipidemia, Previous MYOCARDIAL infarction, Smoking and elevations of CTNI and CK-MB levels weren’t statistically significant.The frequency of increased levels of CTNI and CK-MB in women was significantly higher than men. Conclusion: We concluded that minor cardiac injury following PTCA may increase the serum level of CTNI and serum activity of CK-MB. CTNI is more sensitive than CK-MB in detecting of the injury and placing stent has no effect on the release of the parameters during the PTCA.